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Michel Paques

 
Michel Paques

Clinical Director (MD PhD Professor)

HistoParis Age-related Macular Degeneration Blood flow Flood and Scanning Technology Vascular diseases High speed adaptive optics

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Michel Paques is a surgeon and researcher at the Quinze Vingts National Ophthalmology Hospital and Vision Institute with a focus on scientific and medical applications of high resolution in vivo retinal imaging in humans. He pioneered the development of color fundus cameras for rodents, cell-specific imaging using SLO, and in human the application of adaptive optics ophthalmoscopy for a variety of retinal diseases. 

Publications

Retinal blood flow reversal in out-of-plane vessels imaged with laser Doppler holography

Leo Puyo, Michel Paques, Michael Atlan
22nd August 2020
> https://arxiv.org/abs/2008.09813

The 10q26 risk haplotype of age-related macular degeneration aggravates subretinal inflammation by impairing monocyte elimination

Fanny Beguier, Michael Housset, Christophe Roubeix, Sebastien Augustin, Yvrick Zagar, Caroline Nous, Thibaud Mathis, Chiara Eandi, Mutapha Benchaboune, Adèle Drame-Maigné , Wassila Carpentier, Solenne Chardonnet, Sara Touhami, Guillaume Blot, Jean Baptiste Conart, Hugo Charles-Messance, Anais Potey, Jean-Francois Girmens, Michel Paques, Fréderic Blond, Thierry Leveillard, Elod Koertvely, José-Alain Sahel, Przemyslaw Sapieha, Cécile Delarasse , Xavier Guimmonneau, Florian Sennlaub
https://doi.org/10.1016/j.immuni.2020.07.021
18th August 2020

Trajectory Grouping with Curvature Regularization for Tubular Structure Tracking

Laurent D. Cohen, Li Liu, Da Chen, Minglei Shu, Baesheng Li, Huazhong Shu, Michel Paques
https://hal.archives-ouvertes.fr/hal-02996874/
16th August 2020

Optical Incoherence Tomography: a method to generate tomographic retinal cross-sections with non-interferometric imaging systems

Pedro Mecê, Elena Gofas, Michel Paques, Kate Grieve, Serge Meimon
August 2020
> https://doi.org/10.1364/BOE.396937

Super-resolution in-vivo retinal imaging using structured illumination ophthalmoscopy

Yann Lai-Tim, Laurent Mugnier, Lea Krafft, Antoine Chen, Cyril Petit, Pedro Mecê, Kate Grieve, Michel Paques, Serge Meimon
30th July 2020
> arXiv:2007.16028

Vascular occlusion monitoring in the eye fundus by laser Doppler holography

Leo Puyo, Mathias Fink, Michel Paques, José-Alain Sahel
Biophotonics Congress: Biomedical Optics 2020 (Translational, Microscopy, OCT, OTS, BRAIN), OSA Technical Digest (Optical Society of America, 2020), paper TTu4B.2.
2020
> https://doi.org/https://doi.org/10.1364/TRANSLAT

Multi modal and multi scale retinal imaging with and without adaptive optics for clinical settings.

Muhammad Faizan Shirazi, Jordi Andilla, Marina Cunquero, Nicolas Lefaudeux, Danilo Andrade De Jesus, Luisa Sanchez Brea, Stefan Klein, Theo van Walsum, Kate Grieve, Michel Paques, Michael Larsen, Pablo Loza, Xavier levecq, Nicolas Chateau, Michael Pircher
Invest. Ophthalmol. Vis. Sci. 2020;61(7):3243.
June 2020
> https://iovs.arvojournals.org/article.aspx?articleid=2769801

Dynamic Full-Field OCT to image RPE cell cultures.

Kassandra Groux, Jules Scholler, Anna Verschueren, Marie Darche, Olivier Goureau , José-Alain Sahel, Mathias Fink , Michel Paques, Claude Boccara, Olivier Thouvenin , Sacha Reichman, Kate Grieve
Dynamic Full-Field OCT to image RPE cell cultures. Invest. Ophthalmol. Vis. Sci. 2020;61(7):1867.
June 2020

High resolution structural phenotyping of intermediate and advanced non-neovascular age-related macular degeneration.

Chiara Eandi, Valerie Snyder , Kate Grieve, Kunal Dansingani , Jay Chhablani, Grace Eddy, Andrew Eller, Joseph Martel , Thomas Friberg , Wei Chen, Yvette Perry Conley , José-Alain Sahel, Michel Paques, Ethan Rossi
Invest. Ophthalmol. Vis. Sci. 2020;61(7):210.
June 2020

A new method for visualizing drusen and their progression in adaptive optics ophthalmoscopy.

E Rossi, C Eandi, V Snyder, Kate Grieve, K Dansingani, J Chhablani, Sarah Mrejen, J Martel, José-Alain Sahel, Michel Paques
new method for visualizing drusen and their progression in adaptive optics ophthalmoscopy. Invest. Ophthalmol. Vis. Sci. 2020;61(7):203.
June 2020
> Invest Ophthalmol Vis Sci 3359056

Adaptive Optics SLO motion correction assisted by image similarity. Invest. Ophthalmol. Vis. Sci. 2020;61(7):227.

Danilo Andrade de Jesus , Luisa Sanchez Brea, Kate Grieve, Michel Paques, Nicolas Lefaudeux, Theo van Walsum, Stefan Klein
May 2020
> https://iovs.arvojournals.org/article.aspx?articleid=2769740

Spatio-temporal filtering in laser Doppler holography for retinal blood flow imaging

Leo Puyo, Michel Paques, Michael Atlan
"Spatio-temporal filtering in laser Doppler holography for retinal blood flow imaging," Biomed. Opt. Express 11, 3274-3287 (2020)
May 2020
> 32637254
> https://doi.org/10.1364/BOE.392699

In vivo Observation of Retinal Vacsular Deposits using Adaptive Optics Imaging in Fabry Disease

Sodi, Andrea MD; Germain, Dominique P. MD, PhD; Bacherini, Daniela MD; Finocchio, Lucia MD; Pacini, Bianca MD; Marziali, Elisa MD; Lenzetti, Chiara MD; Tanini, Ilaria MD; Koriachi, Fairouz MD; Coriat, Caroline MD; Nencini, Patrizia MD; Olivotto, lacopo MD; Virgilli, Gianni MD; Rizzo, Stanislao MD; , Michel Paques
Retina
13th May 2020
> https://doi.org/10.1097/IAE.0000000000002648

Curved-field optical coherence tomography: large-field imaging of human corneal cells and nerves

Slava Mazlin, Kristina Irsch, Michel Paques, Mathias Fink, Claude Boccara
arXiv:2004.01016
2nd April 2020

Attenuation Outer Retinal Bands on Optical Coherence Tomography Following Macular EDEMA

Michel Paques, Florence Rossant, Lucia Finocchio , Kate Grieve, José-Alain Sahel, Alexandre Pedinielli, Sarah Mrejen
A Possible Manifestation of Photoreceptor Misalignment
7th January 2020
> https://pubmed.ncbi.nlm.nih.gov/31922497/
> https://doi.org/10.1097/IAE.0000000000002738

Jointly super-resolved and optically sectioned Bayesian reconstruction method for structured illumination microscopy

Yann Lai-Tim, Laurent M. Mugnier, François Orieux, Roberto Baena-Gallé, Michel Paques, Serge Meimon
Jointly super-resolved and optically sectioned Bayesian reconstruction method for structured illumination microscopy," Opt. Express 27, 33251-33267 (2019)
11th November 2019
> https://www.osapublishing.org/oe/abstract.cfm?uri=oe-27-23-33251

New article published in IEEE Transactions in Biomedical Engineering

Florence Rossant, Kate Grieve, Michel Paques
"Highlighting directional reflectance properties of retinal substructures from D-OCT images" IEEE Transactions on Biomedical Engineering ( Early Access ) February 2019.
November 2019
> https://doi.org/10.1109/TBME.2019.2900425

Waveform analysis of human retinal and choroidal blood flow with laser Doppler holography

Leo Puyo, Michel Paques, Mathias Fink, José-Alain Sahel, Michael Atlan
"Waveform analysis of human retinal and choroidal blood flow with laser Doppler holography," Biomed. Opt. Express 10, 4942-4963 (2019)
1st October 2019
> https://www.osapublishing.org/boe/abstract.cfm?uri=boe-10-10-4942

Segmentation of Retinal Arterial Bifurcations in 2D Adaptive Optics Ophthalmoscopy Images

Iyed Trimeche, Florence Rossant, I. Bloch, Michel Paques
Segmentation of retinal arterial bifurcations in 2D adaptive optics ophthalmoscopy images, IEEE International Conference on Image Processing ICIP'19, Taipei, Taiwan, September 2019.
Taipei, Taiwan, 26th August 2019
> https://ieeexplore.ieee.org/document/8803076

Near infrared adaptive optics flood illumination retinal angiography

Elena Gofas, Pedro Mecê, Laurent Mugnier, Aurélie Montmerle Bonnefois, Cyril Petit, Kate Grieve, José-Alain Sahel, Michel Paques, Serge Meimon
"Near infrared adaptive optics flood illumination retinal angiography," Biomed. Opt. Express 10, 2730-2743 (2019)
1st June 2019
> https://www.osapublishing.org/boe/abstract.cfm?uri=boe-10-6-2730

Higher adaptive optics loop rate enhances axial resolution in nonconfocal ophthalmoscopes

Pedro Mecê, Elena Gofas, Cyril Petit, Frédéric Cassaing, José-Alain Sahel, Michel Paques, Kate Grieve, Serge Meimon
"Higher adaptive optics loop rate enhances axial resolution in nonconfocal ophthalmoscopes," Opt. Lett. 44, 2208-2211 (2019)
1st May 2019
> https://www.osapublishing.org/ol/abstract.cfm?uri=ol-44-9-2208

Choroidal vasculature imaging with laser Doppler holography

Leo Puyo, Michel Paques, Mathias Fink, José-Alain Sahel, Michael Atlan
"Choroidal vasculature imaging with laser Doppler holography," Biomed. Opt. Express 10, 995-1012 (2019)
10th February 2019
> https://www.osapublishing.org/boe/abstract.cfm?uri=boe-10-2-995

Deep neural networks for aberration compensation in digital holographic imaging of the retina

Julie Rivet, Guillaume Tochon, Serge Meimon, Michel Paques, Thierry Géraud, Michael Atlan
Adaptive Optics and Wavefront Control for Biological Systems V, Feb 2019, San Francisco, CA, United States. pp.34, ff10.1117/12.2509711ff. ffhal-02176460f
2nd February 2019
> hal-02176460
> https://www.ncbi.nlm.nih.gov/pubmed/https://hal.archives-ouvertes.fr

In vivo near-infrared autofluorescence imaging of retinal pigment epithelial cells with 757 nm excitation

Kate Grieve, Elena Gofas, R. Daniel Ferguson, José-Alain Sahel, Michel Paques, Ethan Rossi
"In vivo near-infrared autofluorescence imaging of retinal pigment epithelial cells with 757 nm excitation," Biomed. Opt. Express 9, 5946-5961 (2018)
1st December 2018
> https://www.osapublishing.org/boe/abstract.cfm?uri=boe-9-12-5946

Directional variability of fundus lesions in acute macular neuroretinopathy

C. Bottin, Kate Grieve, Florence Rossant, A. Pedinielli, Sarah Mrejen, Michel Paques
Retin Cases Brief Rep. 2018 Fall;12 Suppl 1:S19-S24. doi: 10.1097/ICB.0000000000000701.
2018
> https://journals.lww.com/retinalcases/Citation/2018/01241/DIRECTIONAL_VARIABILITY_OF_FUNDUS_REFLECTANCE_IN.6.aspx

Adaptive optics ophthalmoscopy: Application to age-related macular degeneration and vascular diseases

Michel Paques, Serge Meimon, Florence Rossant, David Rosenbaum, Sarah Mrejen, Florian Sennlaub, Kate Grieve
Prog Retin Eye Res. 2018;66:1-16.
1st September 2018
> https://www.ncbi.nlm.nih.gov/pubmed/30010022
> https://doi.org/https://doi.org/10.1016/j.pretey

Adaptive optics opthalmoscopy of dry age-related macular degeneration and vascular diseases

Michel Paques, Serge Meimon, Sarah Mrejen, Florence Rossant, D. Rosenbaum, F. Sennlaub, Kate Grieve
Prog Retin Eye Res. 2018 Sep;66:1-16. doi: 10.1016/j.preteyeres.2018.07.001. Epub 2018 Jul 17.
September 2018
> https://www.sciencedirect.com/science/article/pii/S1350946217300782

Treatment of macular folds complicating retinal detachment surgery using air for retinal unfolding

P. Barale, P. Mora, Marie-Hélène Errera, R. Ores, Michel Paques, José-Alain Sahel
Retinal Cases and Brief Reports, 2018 12 (3), 228-230
1st September 2018
> https://www.osapublishing.org/boe/abstract.cfm?uri=boe-9-9-4113

New prospects in Adaptive-Optics Flood-Illumination retinal imaging

Serge Meimon, Elena Gofas, Pedro Mecê, Cyril Petit, Kate Grieve, L. Mugnier, José-Alain Sahel, Michel Paques
Adaptive Optics: Analysis, Methods & Systems, 2018 OTh4C. 4
2018
> https://www.osapublishing.org/abstract.cfm?uri=AOMS-2018-OTh4C.4
> https://doi.org/10.1364/AOMS.2018.OTh4C.4

Laser Doppler holography of the human retina

Leo Puyo, Michel Paques, Mathias Fink, José-Alain Sahel, Michael Atlan
Biomed Opt Exp Vol. 9, Issue 9, pp. 4113-4129 (2018)
1st September 2018
> https://www.osapublishing.org/boe/abstract.cfm?URI=boe-9-9-4113

High loop rate adaptive optics flood illumination ophthalmoscope with structured illumination capability

Elena Gofas, Pedro Mecê, Cyril Petit, J. Jarosz, Laurent Mugnier, Aurélie Montmerle Bonnefois, Kate Grieve, José-Alain Sahel, Michel Paques, Serge Meimon
Appl. Opt. 57, 5635-5642 (2018)
10th July 2018
> https://www.osapublishing.org/ao/abstract.cfm?uri=ao-57-20-5635

A rationally designed NRP1-independent superagonist SEMA3A mutant is an effective anticancer agent

N. Gioelli, F. Maione, C. Camillo, M. Ghitti, D. Valdembri, N. Morello, Michel Paques, I. Cascone, G. Musco, L. Tamagnone, E. Giraudo, G. Serini
Science Translational Medicine 10 (442), 2018, eaah4807
23rd May 2018
> https://stm.sciencemag.org/content/10/442/eaah4807.short

Fixational eye movement: a negligible source of dynamic aberration

Pedro Mecê, J. Jarosz, JM. Conan, Cyril Petit, Kate Grieve, Michel Paques, Serge Meimon
Biomedical Optics Express 9 (2), 717-727.
1st February 2018
> https://www.osapublishing.org/boe/abstract.cfm?uri=boe-9-2-717&origin=search

Detection and Tracking of the Pores of the Lamina Cribrosa in Three Dimensional SD-OCT Data

Florence Rossant, Kate Grieve, Stéphanie Zwilinger, Michel Paques
ACIVS 2017, Antwerp, Belgium, September 2017
Antwerp, Belgium, 23rd November 2017
> https://link.springer.com/chapter/10.1007/978-3-319-70353-4_55

The 3D Retinal Capillary Circulation in Pigs Reveals a Predominant Serial Organization

S. Fouquet, O. Vacca, F. Sennlaub, Michel Paques
Investigative ophthalmology & visual science 58 (13), 2017, 5754-5763
November 2017
> https://iovs.arvojournals.org/article.aspx?articleid=2662704

Considerations in the understanding of venous outflow in the retinal capillary plexus

ST Garrity, Michel Paques, A. Gaudric, KB. Freund, D. Sarraf
Retina 37 (10), 2017, 1809-1812
October 2017
> https://insights.ovid.com/pubmed?pmid=28737534

Retinal vein occlusions

A. Pierru, JF. Girmens, E. Héron, Michel Paques
Journal francais d'ophtalmologie 40 (8), 2017, 696-705
13th September 2017
> https://europepmc.org/article/med/28916115

Electrophysiological features and multimodal imaging in ritonavir-related maculopathy

C. Faure, Michel Paques, Isabelle Audo
Documenta Ophthalmologica 135 (3), 2017, 241-248
12th September 2017
> https://link.springer.com/article/10.1007%2Fs10633-017-9612-z

Retinal Arterioles Remodeling Assessed By Adaptive Optics In Elderly Hypertensives With Controlled Blood Pressure

D. Rosenbaum, A. Gallo, A. Mattina, Edouard Koch, Florence Rossant, N. Kachenoura, Michel Paques, A. Redheuil, O. Hanon, X Girerd
Journal of Hypertension 35, 2017, e18-e19
September 2017
> https://journals.lww.com/jhypertension/Abstract/2017/09002/_OP_2C_04__RETINAL_ARTERIOLES_REMODELING_ASSESSED.56.aspx

Cell motility as contrast agent in retinal explant imaging with full-field optical coherence tomography

Olivier Thouvenin, Claude Boccara, Mathias Fink, José-Alain Sahel, Michel Paques, Kate Grieve
Invest Ophthalmol Vis Sci. 2017;58:4605???4615. DOI:10.1167/iovs.17-22375
September 2017
> https://iovs.arvojournals.org/article.aspx?articleid=2653947

Vers une reconstruction super-résolue et sectionnée optiquement pour l'imagerie rétinienne par illumination structurée

Yann Lai-Tim, Laurent Mugnier, Francois Orieux, Roberto Baene-Gallé, Michel Paques, Serge Meimon
26th August 2017
> https://hal.archives-ouvertes.fr/hal-02409638

Automated Analysis of Directional Optical Coherence Tomography Images

Florence Rossant, Kate Grieve, Michel Paques
ICIAR'17, Montreal, Canada, July 2017, vol. LNCS 10317, pp 524-532
Montreal, Canada, 2nd June 2017
> https://link.springer.com/chapter/10.1007/978-3-319-59876-5_58

Pupil motion analysis and tracking in ophthalmic systems equipped with wavefront sensing technology.

Serge Meimon, J. Jarosz, Cyril Petit, Elena Gofas, Kate Grieve, JM. Conan, B. Emica, Michel Paques, K. Irsch
Appl. Opt. 2017. 56, D66-D71.
20th March 2017
> https://www.osapublishing.org/ao/abstract.cfm?uri=ao-56-9-D66

Segmentation of retinal vessels in adaptive optics images for assessment of vasculitis

M. Lagarrigue-Charbonnier, Florence Rossant, I. Bloch, Michel Paques, Marie-Hélène Errera
IEEE 6th International Conference on Image Processing Theory, Tools and Applications (IPTA'16)
Oulu, Finland, December 2016
> https://www.researchgate.net/publication/312561240_Segmentation_of_retinal_vessels_in_adaptive_optics_images_for_assessment_of_vasculitis

Appearance of the retina with full-field optical coherence tomography

Kate Grieve, Olivier Thouvenin, A. Sengupta, Vincent Borderie, Michel Paques
Invest Ophthalmol Vis Sci. 2016;57:OCT96???OCT104. DOI:10.1167/iovs.15-18856
10th July 2016
> https://iovs.arvojournals.org/article.aspx?articleid=2535977

Retinal Arteriolar Micro-constrictions Evaluated With Adaptive Optics: A Novel Marker In Hypertension

A. Gallo, A. Mattina, D. Rosenbaum, Edouard Koch, Michel Paques, X. Girerd
Ann Cardiol Angeiol (Paris). 2016 Jun;65(3):203-7. doi: 10.1016/j.ancard.2016.04.021. Epub 2016 May 13
June 2016
> https://www.sciencedirect.com/science/article/pii/S0003392816303122?via%3Dihub

Three-dimensional structure of the mammalian limbal stem cell niche.

Kate Grieve, D. Ghoubay, C. Georgeon, Olivier Thouvenin, N. Bouheraoua, Michel Paques, Vincent Borderie
Exp Eye Res. 2015 Nov;140:75-84. doi: 10.1016/j.exer.2015.08.003. Epub 2015 Aug 20
November 2015
> https://www.sciencedirect.com/science/article/pii/S0014483515002523?via%3Dihub

Fully Automatic Method For Segmenting Retinal Artery Walls in Adaptive Optics Images

N. Lermé, Florence Rossant, I. Bloch, Michel Paques, Edouard Koch, J. Benesty, A
Pattern Recognition Letters, 2016, Vol. 72, pp 72-81.
10th October 2015
> https://www.sciencedirect.com/science/article/abs/pii/S0167865515003621

Parallel Double Snakes. Application to the segmentation of retinal layers in 2D-OCT for pathological subjects

Florence Rossant, I. Bloch, I. Ghorbel, Michel Paques
Pattern Recognition 48 (2015), pp. 3857-3870
2015
> https://www.sciencedirect.com/science/article/pii/S0031320315002319

Segmentation of Retinal Arteries in Adaptive Optics Images

N. Lermé, Florence Rossant, I. Bloch, Michel Paques, Edouard Koch
International Conference on Pattern Recognition (ICPR 2014), pp 574-578
Stockholm, Sweden, August 2014 , Best Scientific Paper Award, Track Biomedical Image Analysis.
> https://ieeexplore.ieee.org/document/6976819/