Kate Grieve

Scientific Director (PhD)

Kate Grieve is the Scientific Director of the Paris Eye Imaging unit.

Since 2014 she has been responsible for development and application of in vivo high resolution ocular imaging technologies at the Quinze Vingts National Ophthalmology Hospital and Vision Institute. She is a leading specialist in both full field optical coherence tomography, in collaboration with Claude Boccara and team at the Langevin Institute, and in adaptive optics technology, as a postdoc with Austin Roorda at UC Berkeley and Martin Booth at University of Oxford, and in current collaboration with Ethan Rossi at University of Pittsburgh Medical Center and Serge Meimon at ONERA. She has successfully completed and is currently principal or co-investigator on various ANR, European Research Council, FFB and internally funded grants to develop optical imaging technologies for ophthalmology and vision applications. In addition to her academic activities, she has worked in industry as an optical engineer, commercializing innovative retinal imaging technologies.

Publications

Dynamic full-field optical coherence tomography: 3D live-imaging of retinal organoids

Jules Scholler, Kassandra Groux, Olivier Goureau, José-Alain Sahel, Mathias Fink, Sacha Reichman, Claude Boccara, Kate Grieve

Light Sci Appl 9, 140 (2020)

17th August 2020

> https://doi.org/https://doi.org/10.1038/s41377-0

Optical Incoherence Tomography: a method to generate tomographic retinal cross-sections with non-interferometric imaging systems

Pedro Mecê, Elena Gofas, Michel Paques, Kate Grieve, Serge Meimon

August 2020

> https://doi.org/10.1364/BOE.396937

Super-resolution in-vivo retinal imaging using structured illumination ophthalmoscopy

Yann Lai-Tim, Laurent Mugnier, Lea Krafft, Antoine Chen, Cyril Petit, Pedro Mecê, Kate Grieve, Michel Paques, Serge Meimon

30th July 2020

> arXiv:2007.16028

Dynamic Full-Field OCT to image RPE cell cultures.

Kassandra Groux, Jules Scholler, Anna Verschueren, Marie Darche, Olivier Goureau , José-Alain Sahel, Mathias Fink , Michel Paques, Claude Boccara, Olivier Thouvenin , Sacha Reichman, Kate Grieve

Dynamic Full-Field OCT to image RPE cell cultures. Invest. Ophthalmol. Vis. Sci. 2020;61(7):1867.

June 2020

High resolution structural phenotyping of intermediate and advanced non-neovascular age-related macular degeneration.

Chiara Eandi, Valerie Snyder , Kate Grieve, Kunal Dansingani , Jay Chhablani, Grace Eddy, Andrew Eller, Joseph Martel , Thomas Friberg , Wei Chen, Yvette Perry Conley , José-Alain Sahel, Michel Paques, Ethan Rossi

Invest. Ophthalmol. Vis. Sci. 2020;61(7):210.

June 2020

A new method for visualizing drusen and their progression in adaptive optics ophthalmoscopy.

E Rossi, C Eandi, V Snyder, Kate Grieve, K Dansingani, J Chhablani, Sarah Mrejen, J Martel, José-Alain Sahel, Michel Paques

new method for visualizing drusen and their progression in adaptive optics ophthalmoscopy. Invest. Ophthalmol. Vis. Sci. 2020;61(7):203.

June 2020

> Invest Ophthalmol Vis Sci 3359056

Adaptive Optics SLO motion correction assisted by image similarity. Invest. Ophthalmol. Vis. Sci. 2020;61(7):227.

Danilo Andrade de Jesus , Luisa Sanchez Brea, Kate Grieve, Michel Paques, Nicolas Lefaudeux, Theo van Walsum, Stefan Klein

May 2020

> https://iovs.arvojournals.org/article.aspx?articleid=2769740

Corneal stromal stem cells restore transparency after N 2 injury in mice. Stem Cells Translational Medicine 2020.

D Ghoubay , M Borderie, Kate Grieve, R Martos

7th May 2020

> https://doi.org/https://doi.org/10.1002/sctm.19-

Real-time non-contact cellular imaging and angiography of human cornea and limbus with common-path full-field/SD-OCT.

Slava Mazlin, Xiao P , Jules Scholler, Irsch K, Kate Grieve, Fink M, Claude Boccara

Nature communications 11(1), 1-14

2020

> https://doi.org/https://doi.org/10.1038/s41467-0

Attenuation Outer Retinal Bands on Optical Coherence Tomography Following Macular EDEMA

Michel Paques, Florence Rossant, Lucia Finocchio , Kate Grieve, José-Alain Sahel, Alexandre Pedinielli, Sarah Mrejen

A Possible Manifestation of Photoreceptor Misalignment

7th January 2020

> https://pubmed.ncbi.nlm.nih.gov/31922497/

> https://doi.org/10.1097/IAE.0000000000002738

Multimodal Imaging Features of Schnyder Corneal Dystrophy.

Ghazal W, Georgeon C, Kate Grieve, Bouheraoua N, Borderie V

J Ophthalmol 2020.

31st December 2019

Dynamic full-field optical coherence tomography: 3D live-imaging of retinal organoids. arXiv preprint.

Jules Scholler, Kassandra Groux, Goureau O , José-Alain Sahel, Fink M, Reichman S, Claude Boccara, Kate Grieve

arXiv:1912.04052, 2019 (in review Light: Science and Applications 2020).

2019

New article published in IEEE Transactions in Biomedical Engineering

Florence Rossant, Kate Grieve, Michel Paques

"Highlighting directional reflectance properties of retinal substructures from D-OCT images" IEEE Transactions on Biomedical Engineering ( Early Access ) February 2019.

November 2019

> https://doi.org/10.1109/TBME.2019.2900425

Near infrared adaptive optics flood illumination retinal angiography

Elena Gofas, Pedro Mecê, Laurent Mugnier, Aurélie Montmerle Bonnefois, Cyril Petit, Kate Grieve, José-Alain Sahel, Michel Paques, Serge Meimon

"Near infrared adaptive optics flood illumination retinal angiography," Biomed. Opt. Express 10, 2730-2743 (2019)

1st June 2019

> https://www.osapublishing.org/boe/abstract.cfm?uri=boe-10-6-2730

Higher adaptive optics loop rate enhances axial resolution in nonconfocal ophthalmoscopes

Pedro Mecê, Elena Gofas, Cyril Petit, Frédéric Cassaing, José-Alain Sahel, Michel Paques, Kate Grieve, Serge Meimon

"Higher adaptive optics loop rate enhances axial resolution in nonconfocal ophthalmoscopes," Opt. Lett. 44, 2208-2211 (2019)

1st May 2019

> https://www.osapublishing.org/ol/abstract.cfm?uri=ol-44-9-2208

Probing dynamic processes in the eye at multiple spatial and temporal scales with multimodal full field OCT

Jules Scholler, Viacheslav Mazlin, Olivier Thouvenin, Kassandra Groux, Peng Xiao, José-Alain Sahel, Mathias Fink, Claude Boccara, Kate Grieve

"Probing dynamic processes in the eye at multiple spatial and temporal scales with multimodal full field OCT," Biomed. Opt. Express 10, 731-746 (2019)

1st February 2019

> https://www.osapublishing.org/boe/abstract.cfm?uri=boe-10-2-731

Multimodal imaging of pre-Descemet corneal dystrophy. European J Opthalmol, 1120672119862505, 2019.

Alafaleq M, Georgeon C, Kate Grieve, Borderie V

2018

In vivo near-infrared autofluorescence imaging of retinal pigment epithelial cells with 757 nm excitation

Kate Grieve, Elena Gofas, R. Daniel Ferguson, José-Alain Sahel, Michel Paques, Ethan Rossi

"In vivo near-infrared autofluorescence imaging of retinal pigment epithelial cells with 757 nm excitation," Biomed. Opt. Express 9, 5946-5961 (2018)

1st December 2018

> https://www.osapublishing.org/boe/abstract.cfm?uri=boe-9-12-5946

Directional variability of fundus lesions in acute macular neuroretinopathy

C. Bottin, Kate Grieve, Florence Rossant, A. Pedinielli, Sarah Mrejen, Michel Paques

Retin Cases Brief Rep. 2018 Fall;12 Suppl 1:S19-S24. doi: 10.1097/ICB.0000000000000701.

2018

> https://journals.lww.com/retinalcases/Citation/2018/01241/DIRECTIONAL_VARIABILITY_OF_FUNDUS_REFLECTANCE_IN.6.aspx

Adaptive optics ophthalmoscopy: Application to age-related macular degeneration and vascular diseases

Michel Paques, Serge Meimon, Florence Rossant, David Rosenbaum, Sarah Mrejen, Florian Sennlaub, Kate Grieve

Prog Retin Eye Res. 2018;66:1-16.

1st September 2018

> https://www.ncbi.nlm.nih.gov/pubmed/30010022

> https://doi.org/https://doi.org/10.1016/j.pretey

Adaptive optics opthalmoscopy of dry age-related macular degeneration and vascular diseases

Michel Paques, Serge Meimon, Sarah Mrejen, Florence Rossant, D. Rosenbaum, F. Sennlaub, Kate Grieve

Prog Retin Eye Res. 2018 Sep;66:1-16. doi: 10.1016/j.preteyeres.2018.07.001. Epub 2018 Jul 17.

September 2018

> https://www.sciencedirect.com/science/article/pii/S1350946217300782

New prospects in Adaptive-Optics Flood-Illumination retinal imaging

Serge Meimon, Elena Gofas, Pedro Mecê, Cyril Petit, Kate Grieve, L. Mugnier, José-Alain Sahel, Michel Paques

Adaptive Optics: Analysis, Methods & Systems, 2018 OTh4C. 4

2018

> https://www.osapublishing.org/abstract.cfm?uri=AOMS-2018-OTh4C.4

> https://doi.org/10.1364/AOMS.2018.OTh4C.4

High loop rate adaptive optics flood illumination ophthalmoscope with structured illumination capability

Elena Gofas, Pedro Mecê, Cyril Petit, J. Jarosz, Laurent Mugnier, Aurélie Montmerle Bonnefois, Kate Grieve, José-Alain Sahel, Michel Paques, Serge Meimon

Appl. Opt. 57, 5635-5642 (2018)

10th July 2018

> https://www.osapublishing.org/ao/abstract.cfm?uri=ao-57-20-5635

In vivo high-resolution human retinal imaging with wavefront-correctionless full-field OCT

Peng Xiao, Viacheslav Mazlin, Kate Grieve, José-Alain Sahel, Mathias Fink, Claude Boccara

Optica 5 (4), 409-412.

20th April 2018

> https://www.osapublishing.org/optica/abstract.cfm?uri=optica-5-4-409

Fixational eye movement: a negligible source of dynamic aberration

Pedro Mecê, J. Jarosz, JM. Conan, Cyril Petit, Kate Grieve, Michel Paques, Serge Meimon

Biomedical Optics Express 9 (2), 717-727.

1st February 2018

> https://www.osapublishing.org/boe/abstract.cfm?uri=boe-9-2-717&origin=search

In vivo high resolution human corneal imaging using full-field optical coherence tomography

Viacheslav Mazlin, Peng Xiao, E. Dalimier, Kate Grieve, K. Irsch, José-Alain Sahel, Mathias Fink, Claude Boccara

Biomedical Optics Express 9 (2), 557-568.

1st February 2018

> https://www.osapublishing.org/boe/abstract.cfm?uri=boe-9-2-557&origin=search

Detection and Tracking of the Pores of the Lamina Cribrosa in Three Dimensional SD-OCT Data

Florence Rossant, Kate Grieve, Stéphanie Zwilinger, Michel Paques

ACIVS 2017, Antwerp, Belgium, September 2017

Antwerp, Belgium, 23rd November 2017

> https://link.springer.com/chapter/10.1007/978-3-319-70353-4_55

Stromal striae: a new insight into corneal physiology and mechanics

Kate Grieve, D. Ghoubay, C. Georgeon, R. Bocheux, G. Latour, M. Borderie, A. Nahas, TM. Nguyen, MC. Schanne-Klein, F. Andreiuolo, Vincent Borderie

Scientific Reports 7 (1), 13584 2017.

19th October 2017

> https://www.nature.com/articles/s41598-017-13194-6

Cell motility as contrast agent in retinal explant imaging with full-field optical coherence tomography

Olivier Thouvenin, Claude Boccara, Mathias Fink, José-Alain Sahel, Michel Paques, Kate Grieve

Invest Ophthalmol Vis Sci. 2017;58:4605�??4615. DOI:10.1167/iovs.17-22375

September 2017

> https://iovs.arvojournals.org/article.aspx?articleid=2653947

Automated Analysis of Directional Optical Coherence Tomography Images

Florence Rossant, Kate Grieve, Michel Paques

ICIAR'17, Montreal, Canada, July 2017, vol. LNCS 10317, pp 524-532

Montreal, Canada, 2nd June 2017

> https://link.springer.com/chapter/10.1007/978-3-319-59876-5_58

Full-field OCT technique for high speed event-based optical flow and particle tracking.

X. Berthelon, G. Chenegros, N. Libert, José-Alain Sahel, Kate Grieve, R. Benosman

Opt Express. 2017. 29;25(11):12611-12621.

29th May 2017

> https://www.osapublishing.org/oe/abstract.cfm?uri=oe-25-11-12611&origin=search

Pupil motion analysis and tracking in ophthalmic systems equipped with wavefront sensing technology.

Serge Meimon, J. Jarosz, Cyril Petit, Elena Gofas, Kate Grieve, JM. Conan, B. Emica, Michel Paques, K. Irsch

Appl. Opt. 2017. 56, D66-D71.

20th March 2017

> https://www.osapublishing.org/ao/abstract.cfm?uri=ao-56-9-D66

New Parameters in Assessment of Human Donor Corneal Stroma

M. Borderie, Kate Grieve, D. Ghoubay, C. Georgeon, C. De Sousa, L. Laroche, Vincent Borderie

Acta Ophthalmol. 2017. doi:10.1111/aos.13351

30th January 2017

> https://onlinelibrary.wiley.com/doi/full/10.1111/aos.13351

En face coherence microscopy

Olivier Thouvenin, Kate Grieve, Peng Xiao, Claude Boccara

Biomed. Opt. Express 2017; 8, 622-639, special issue OCT. Invited paper.

10th January 2017

> https://www.osapublishing.org/boe/abstract.cfm?uri=boe-8-2-622

Imaging Microscopic Features of Keratoconic Corneal Morphology

Kate Grieve, C. Georgeon, F. Andreiuolo, AL.

Cornea. 2016;35(12):1621-1630. doi:10.1097/ICO.0000000000000979.

25th August 2016

> https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5094201/

Appearance of the retina with full-field optical coherence tomography

Kate Grieve, Olivier Thouvenin, A. Sengupta, Vincent Borderie, Michel Paques

Invest Ophthalmol Vis Sci. 2016;57:OCT96�??OCT104. DOI:10.1167/iovs.15-18856

10th July 2016

> https://iovs.arvojournals.org/article.aspx?articleid=2535977

Three-dimensional structure of the mammalian limbal stem cell niche.

Kate Grieve, D. Ghoubay, C. Georgeon, Olivier Thouvenin, N. Bouheraoua, Michel Paques, Vincent Borderie

Exp Eye Res. 2015 Nov;140:75-84. doi: 10.1016/j.exer.2015.08.003. Epub 2015 Aug 20

November 2015

> https://www.sciencedirect.com/science/article/pii/S0014483515002523?via%3Dihub